Studies on Experimental Fever with Particular Reference to the Pathogenetic Role and Chemical Properties of Leucocytic Pyrogen.
نویسندگان
چکیده
Fever is a very common manifestation of disease. Its value as a diagnostic sign. has been recognized for more than 20 centuries,1 and yet the precise mechanisms which cause it are still unknown. About a hundred years ago, a group of German clinicians and pathologists2-4 advanced the theory that fever is in some way related to inflammation. This hypothesis was supported by the demonstration that purulent exudates contain an extractable component which, if injected intravenously, causes fever.3-5 The temperature chart in Figure 1 depicts the response of a cat given an intra-
منابع مشابه
Observations on the Production of Pyrogenic Substances by Rabbit and Human Leucocytes
1. The mechanism of release of a pyrogen from leucocytes has been studied in cells obtained from sterile rabbit peritoneal exudates and from rabbit blood. Attempts were made to induce human leucocytes-from blood-to release a pyrogen. 2. Rabbit leucocytes, kept below 4 degrees C., were not pyrogenic and did not release any pyrogen when disintegrated. Incubating such cells, in various media, at 3...
متن کاملStudies on the Pathogenesis of Fever
The production of endogenous pyrogen by intact granulocytes obtained from acute peritoneal exudates is blocked by arsenite, iodoacetate, p-chloromercuribenzoate, and N-ethylmaleimide in concentrations of 2 x 10(-4)M. When the concentration of these sulfhydryl-reactive enzyme inhibitors is increased to 2 x 10(-2)M, only the iodoacetate inactivates the pyrogen molecule, whereas the arsenite, the ...
متن کاملSTUDIES ON THE PATHOGENESIS OF FEVER I. THE PRESENCE OF TRANSFERABLE PYROGEN IN l'lJ.z BLOOD STREAM FOLLOWING THE INJECTION OF TYPHOID VACCr_NE* BY ELISHA
Body temperature is controlled by thermoregulatory centers of the brain. Except in conditions involving direct injury to the central nervous system, however, the manner in which these centers are influenced by diseases which give rise to fever is not known (1-3). Numerous studies relating to the problem have been performed with rabbits injected intravenously with pyrogenic substances of bacteri...
متن کاملSTUDIES ON THE PATHOGENESIS OF FEVER V. Tm~ P~LATION OF CmCULATmO ENDOGENOUS PYROGEN TO THE FEVER OF ACUTE BACTERIAL INI~CTIONS* BY M. KENTON
A circulating endogenous pyrogen, which acts directly on the thermoregulatory centers of the brain (1), has been demonstrated in the blood of rabbits with fever produced by the intravenous injection of typhoid vaccine (2, 3). Bennett, Petersdorf, and Keene have recently reported that bacterial endotoxins may also, under special circumstances, exert a direct pyrogenic action on the central nervo...
متن کاملPathogenetic Mechanisms in Experimental Immune Fever
When rabbits sensitized to human serum albumin (HSA) are challenged intravenously with specific antigen, fever develops and two transferable pyrogens can be demonstrated in the circulation. The first appears prior to the development of fever and has properties consistent with soluble antigen-antibody complexes. These have been shown to be pyrogenic when prepared in vitro and to produce a state ...
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عنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 46 9 شماره
صفحات -
تاریخ انتشار 1960